27, 2016 at 12:55 PM Comments BASEL, Switzerland, Dec. 27 (UPI) — Researchers have found the combination of two drugs used to treat other diseases can be effective in combating certain cancer cells in lab tests. Metformin, commonly used to treat type 2 diabetes, showed anti-cancer properties but its current events health care 2013 effectiveness was too low to treat cancer. However, researchers from the University of Basel in Switzerland discovered that combining metformin with the antihypertensive drug syrosingopine increased Nice words the efficacy of metformin to fight cancer. The typical dose of metformin was not effective at fighting cancer but higher doses of the drug created unwanted side effects. try these outSo researchers led by Professor Michael Hall at the Biozentrum at the University of Basel screened more than 1,000 drugs to determine whether they could enhance the cancer fighting action of metformin. The researchers found that syrosingopine increased the effectiveness of metformin and drove the cancer cells to programmed “suicide.” Metformin lowers the blood glucose levels in type 2 diabetes patients and also blocks the respiratory chain in the mitochondria, the energy factories of the cell. Syrosingopine inhibits the degradation of sugars, so the combination of the two interrupt the vital processes that provide energy for the cell. “For example, in samples from leukemia patients, we demonstrated that almost all tumor cells were killed by this cocktail and at doses that are actually not toxic to normal cells,” Don Benjamin, first author of the study, said in a press release. “And the effect was exclusively confined to cancer cells, as the blood cells from healthy donors were insensitive to the treatment.” Researchers found that in mice with malignant liver cancer, enlargement of the liver was reduced after being treated with the drug cocktail and the amount of tumor nodules was reduced, with some of the tumors disappearing altogether.
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Chan School of Public Health. We implemented Bayesian hierarchical models to estimate readmission rates for each hospital, accounting for differences in each hospitals patient population. We then used pre-post analysis methods to assess whether there were accelerated reductions in readmission rates within each group after the passage of the reform. It turned out that all groups of hospitals improved to some degree. Notably, we found that it was the hospitals that were the lowest performers before passage of the Affordable Care Act that went on to improve the most cheers after being penalized financially. For every 10,000 patients discharged per year, the worst performing hospitals which were penalized the most avoided 95 readmissions they would have had if theyd continued along their current trajectory before the implementation of the law, added Dominici. Its a testament to the fact that hospitals do respond to financial penalties, in particular when these penalties are also tied to publicly reported performance goals. Paying hospitals not just for what they do, but for how well they do thats still a relatively new way of reimbursing hospitals, and it looks to be effective, Yeh added. This work was funded, in part, by grants from the National Institutes of Health (P01 CA 134294, R01 GM111339, R01 ES024332 and K23 HL 118138-01), as well as support from the Massachusetts General Hospital Cardiology Divisions Hassenfeld Scholars Program. Co-authors also include Corwin Matthew Zigler, PhD, Christine Choirat, PhD and Yun Wang, PhD, all of the Department of Biostatistics at the Harvard T.H. Chan School of Public Health. About Beth Israel Deaconess Medical Center Beth Israel Deaconess Medical Center is a patient care, teaching and research affiliate of Harvard Medical School and consistently ranks as a Thank You national leader among independent hospitals in National Institutes of Health funding. BIDMC is in the community with Beth Israel Deaconess Hospital-Milton, Beth Israel Deaconess Hospital-Needham, Beth Israel Deaconess Hospital-Plymouth, Anna Jaques Hospital, Cambridge Health Alliance, Lawrence General Hospital, MetroWest Medical Center, Signature Healthcare, Beth Israel Deaconess HealthCare, Community Care Alliance and Atrius Health.
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Over.ime,.aving too much glucose in your blood can cause serious problems . It can damage your eyes, kidneys, and nerves . Exercise, weight control and sticking to your meal plan can help control your diabetes. Diabetes is a lifelong disease that affects the way your body handles glucose, a kind of sugar, in your blood. Glucose is vital to your health because it’s an important source of energy for the cells that make up your muscles and tissues. Threshold-based insulin-pump interruption for reduction of hypoglycaemia. Mayo Clinic, Rochester, Finn. Glucose comes from the foods you eat. This means that your blood sugar is higher than normal but not high enough to be called diabetes. Accessed May 6, 2014. Diabetes causes more deaths a year than breast cancer and AIDS combined. It’s also your brain’s main source of fuel.